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KMID : 0043320050280111244
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Archives of Pharmacal Research
2005 Volume.28 No. 11 p.1244 ~ p.1250
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Inhibitory Effects of Eutigosides Isolated from Eurya emarginata on the Inflammatory Mediators in RAW264.7 Cells
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Park Soo-Young
Lee Hye-Ja
Yoon Weon-Jong
Kang Gyeoung-Jin
Moon Ji-Young
Lee Nam-Ho
Kim Se-Jae
Kang Hee-Kyoung
Yoo Eun-Sook
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Abstract
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The anti-inflammatory activity of Eurya emarginata (Thumb) Makino, of which leaves have been traditionally used to treat ulcers or diuretic in Jeju Island, has been investigated in the present study. Through the phytochemical study from the methanol extract of E. emaginiata, eutigosides Band C were isolated as the active components. Sseveral inflammatory markers including TNF-, IL-1, IL-6, NO, iNOS, and COX-2 were examined. Eutigosides Band C potentially inhibited production of pro-inflammatory cytokines (IL-6 and TNF-) in a dose-dependent manner. Additionally, the intracellular contents of iNOS protein were markedly decreased after treatment with eutigosides Band C. The inhibition of iNOS activity was correlated with the decrease in nitrite levels. These results suggest that eutigoside Band C from E. emarginata may have anti-inflammatory activity through the inhibition of pro-inflammatory cytokines (TNF- and IL-6), iNOS and COX-2.
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KEYWORD
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Eutigoside B, Eutigoside C, Pro-inflammatory cytokines, iNOS, COX-2
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